Fungi play significant roles in causing diseases across various organisms within both the plant and animal realms, encompassing humans as well. Due to the widespread use of antifungals in both agricultural practices and modern medical treatments, the incidence of resistant fungal infections has been increasing. The challenge of escalating antifungal resistance is worsened by the lack of new antifungal agents under development, especially those with distinctive mechanisms of action. Antifungal resistance in veterinary medicine is also a growing concern, yet comprehensive data on animal fungal infections remains scarce. This paper explores the limited array of antifungal drugs, mechanisms underlying resistance, and strategies to combat this issue.
Keywords: Anti-fungal resistance, animals, histoplasmosis, therapy, mechanisms